The Art of Translation: Molecular Innovation in RNA and Immunity

Immunobiochemistry Lab – Institute of Clinical Chemistry and Clinical Pharmacology (IKCKP) at University Hospital Bonn & University of Bonn

Research

How is translation regulated by the ribosome?

We unravel how ribosomal RNA of the ribosome recognizes specific mRNAs for selective translation. ⟶

How is translation regulated in the innate immune response?

We decipher the impact of selective translation in key regulatory processes such as innate immunity.

Development of versatile RNA-centric technologies and ribosome engineering

We develop and optimize RNA-based strategies to answer difficult questions in fundamental biology. ⟶

How can discoveries in selective translation inform the development of RNA therapeutics?

We harness our basic science findings to develop new mRNA therapeutics. ⟶

Team

Kathrin Leppek
Team Leader / PI
Vivian Lobo
Postdoctoral Researcher
Martin Haiman
PhD Student
Samyukta Narayanan
PhD Student
Philipp Koch
PhD Student
Aiswarya Gopal
PhD Student

Publications

Discover our Contributions to Translation & Immunology

Our lab aims to understand how the ribosome regulates species-specific, selective translation and how these principles are employed in innate immunity. We combine the disciplines of RNA biochemistry and ribosome biology with innate immunity to understand detailed molecular mechanisms in health and disease. We also develop RNA-centric tools that enable the investigation of RNA design principles for therapeutic purposes.

To read more about our research, see our research and publications.

(Image Credit: Myles Marshall, NYC)

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